Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species.

Authors :: Schell WA
Jones AM
Borroto-Esoda K
Alexander BD
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Oct 24; Vol. 61 (11). Date of Electronic Publication: 2017 Oct 24 (Print Publication: 2017).
Publication Year :: 2017
Abstract: SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans , Candida dubliniensis , Candida glabrata , Candida krusei , Candida lusitaniae , and Candida parapsilosis , including 44 Candida isolates with known genotypic ( FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.<br /> (Copyright © 2017 American Society for Microbiology.)

Subjects :: Anidulafungin
Candida isolation & purification
Echinocandins pharmacology
Humans
Microbial Sensitivity Tests
Voriconazole pharmacology
Antifungal Agents pharmacology
Candida drug effects
Drug Resistance, Fungal drug effects
Glycosides pharmacology
Triterpenes pharmacology

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