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Executive function and cardiac autonomic regulation in depressive disorders.
- Source :
-
Brain and cognition [Brain Cogn] 2017 Nov; Vol. 118, pp. 108-117. Date of Electronic Publication: 2017 Aug 18. - Publication Year :
- 2017
-
Abstract
- Executive function impairments have been frequently observed in depressive disorders. Moreover, reduced heart rate variability (HRV) has repeatedly been described, especially in the high frequency band (i.e., respiratory sinus arrhythmia, RSA), suggesting lower vagal cardiac outflow. The study tested the hypothesis of involvement of low vagal tone in executive dysfunction in depression. In addition to RSA, HRV in the low frequency (LF) band was assessed. In 36 patients with depression and 36 healthy subjects, electrocardiography recordings were accomplished at rest and during performance of five executive function tasks (number-letter task, n-back task, continuous performance test, flanker task, and antisaccade task). Patients displayed increased error rates and longer reaction times in the task-switching condition of the number-letter task, in addition to increased error rates in the n-back task and the final of two blocks of the antisaccade task. In patients, both HRV parameters were lower during all experimental phases. RSA correlated negatively with reaction time during task-switching. This finding confirms reduced performance across different executive functions in depression and suggests that, in addition to RSA, LF HRV is also diminished. However, the hypothesis of involvement of low parasympathetic tone in executive dysfunction related to depression received only limited support.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Cognitive Dysfunction etiology
Depressive Disorder complications
Female
Humans
Male
Young Adult
Autonomic Nervous System physiopathology
Cognitive Dysfunction physiopathology
Depressive Disorder physiopathology
Executive Function physiology
Heart Rate physiology
Respiratory Sinus Arrhythmia physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2147
- Volume :
- 118
- Database :
- MEDLINE
- Journal :
- Brain and cognition
- Publication Type :
- Academic Journal
- Accession number :
- 28826051
- Full Text :
- https://doi.org/10.1016/j.bandc.2017.08.003