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Further Molecular Analysis of G6PD Deficiency Variants in Southern Vietnam and a Novel Variant Designated as G6PD Ho Chi Minh (173 A>G; 58 Asp>Gly): Frequency Distributions of Variants Compared with Those in Other Southeast Asian Countries.
- Source :
-
Acta medica Okayama [Acta Med Okayama] 2017 Aug; Vol. 71 (4), pp. 325-332. - Publication Year :
- 2017
-
Abstract
- We conducted a survey of glucose-6-phosphate dehydrogenase (G6PD) deficiency among newborn babies at Tu Du Hospital, Ho Chi Minh, southern Vietnam. A total of 90 deficient babies were detected, including 85 in the Kinh ethnic group, 4 Chinese, and 1 in the K'Ho minority group. In the Kinh ethnic group, G6PD variants such as G6PD Viangchan (n=32), Kaiping (n=11), Canton (n=8), Chinese-5 (n=7), Union (n=5) and Quing Yuan (n=4) were detected. A variant with silent mutations at 1311 C>T and IVS11 nt 93 T>C was also detected in 17 cases. A novel mutation (173 A>G) in exon 4 with a predicted amino acid change of 58 Asp>Gly was also found in a Kinh newborn girl and her father, and it was designated as G6PD Ho Chi Minh. These findings demonstrated that the Kinh ethnic group in southern Vietnam has 8 different G6PD variants, indicating that the members of this group have many ancestors in terms of G6PD variants from Southeast Asia, China, and Oceania. We compared the frequency distribution of G6PD variants in the Kinh population with those of other Southeast Asian populations, and the Kinh population's distribution was quite similar to that in the Thai population, but differed from it by the absence of G6PD Mahidol.<br />Competing Interests: No potential conflict of interest relevant to this article was reported.
- Subjects :
- Demography
Ethnicity
Glucosephosphate Dehydrogenase Deficiency ethnology
Humans
Vietnam epidemiology
Genetic Variation genetics
Glucosephosphate Dehydrogenase genetics
Glucosephosphate Dehydrogenase metabolism
Glucosephosphate Dehydrogenase Deficiency epidemiology
Glucosephosphate Dehydrogenase Deficiency genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0386-300X
- Volume :
- 71
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta medica Okayama
- Publication Type :
- Academic Journal
- Accession number :
- 28824188
- Full Text :
- https://doi.org/10.18926/AMO/55309