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Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2017 Oct; Vol. 27 (10), pp. 910-918. Date of Electronic Publication: 2017 Jul 08. - Publication Year :
- 2017
-
Abstract
- Background and Aim: Recent studies have reported beneficial effects of specific probiotics on obesity. However, the difference in the anti-obesity effects of probiotics as single species and dual species is still uncertain. Therefore, we aimed to compare the efficacy of single and dual species of bacteria on markers of obesity in high-fat diet-induced obese rats.<br />Methods and Results: A total of 40 male Sprague-Dawley rats were assigned to one of five groups of varying diets as follows: standard diet, high fat diet (HFD), HFD supplemented with Lactobacillus casei strain Shirota, HFD supplemented with Bifidobacterium longum and HFD supplemented with a mixture of these two bacterial species. After 15 weeks of supplementation, the animals were examined for changes in body weight, body fat, total count of bacteria in fecal, blood serum lipid profile, leptin, adiponectin and inflammatory biomarkers. Histological analysis of the liver and adipose tissue was performed and the hepatic mRNA expression levels of genes related to lipid metabolism were measured. It was found that probiotic supplementation of either B. longum or a mixture of B. longum and LcS bacteria significantly reduced weight and triglycerides in the HFD groups. Supplementation of B. longum bacteria showed better results in terms of modulating leptin level, fat mass, adipocyte size and lipoprotein lipase expression, as well as increasing adiponectin and peroxisome proliferator-activated receptors-γ expression compared to dual species of bacteria. No significant differences were observed in the total count of fecal bacteria, glucose and inflammatory biomarker levels between supplemented groups.<br />Conclusions: B. longum supplementation in obesity was more beneficial in metabolic profile changes than the mixture species.<br /> (Copyright © 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adipokines blood
Adiposity drug effects
Animals
Biomarkers blood
Cytokines blood
Diet, High-Fat
Disease Models, Animal
Feces microbiology
Gene Expression Regulation
Inflammation Mediators blood
Lipids blood
Male
Obesity blood
Obesity microbiology
Obesity physiopathology
Rats, Sprague-Dawley
Time Factors
Bifidobacterium longum growth & development
Gastrointestinal Microbiome
Intestines microbiology
Lacticaseibacillus casei growth & development
Obesity therapy
Probiotics administration & dosage
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 27
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 28821417
- Full Text :
- https://doi.org/10.1016/j.numecd.2017.06.020