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Presence of quintuple dhfr N51, C59, S108 - dhps A437, K540 mutations in Plasmodium falciparum isolates from pregnant women and the general population in Nanoro, Burkina Faso.
- Source :
-
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2017 Oct; Vol. 217, pp. 13-15. Date of Electronic Publication: 2017 Aug 14. - Publication Year :
- 2017
-
Abstract
- Sulphadoxine-pyrimethamine (SP) is only used for intermittent preventive treatment during pregnancy (IPTp) in most Sub-Saharan African countries. However, there are concerns about the efficacy of IPTp-SP because of increasing resistance. Combinations of point mutations in the dhps and dhfr genes of Plasmodium falciparum are associated with SP resistance, in particular the quintuple dhfr (N51, C59, S108) - dhps (codons A437, K540) mutant. In Nanoro, Burkina Faso, filter paper samples from pregnant women at first antenatal care visit and at delivery plus samples from the general population (GP) were studied for dhfr and dhps mutations by sequencing. Quintuple mutants were present in 2 delivery and 4 GP samples. This is the first time the quintuple mutation is found in Burkina Faso and although the prevalence is still very low, emergence of the quintuple mutation could highly diminish the efficacy of IPTp-SP. Close surveillance of SP resistance mutations is therefore warranted.<br /> (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Amino Acid Substitution
Antimalarials pharmacology
Antimalarials therapeutic use
Burkina Faso epidemiology
Child
Child, Preschool
Drug Combinations
Female
Humans
Infant
Malaria, Falciparum drug therapy
Male
Middle Aged
Parasomnias
Plasmodium falciparum drug effects
Pregnancy
Pregnancy Complications, Parasitic drug therapy
Pyrimethamine pharmacology
Pyrimethamine therapeutic use
Sulfadoxine pharmacology
Sulfadoxine therapeutic use
Young Adult
Malaria, Falciparum epidemiology
Malaria, Falciparum parasitology
Plasmodium falciparum genetics
Pregnancy Complications, Parasitic epidemiology
Protozoan Proteins genetics
Tetrahydrofolate Dehydrogenase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9428
- Volume :
- 217
- Database :
- MEDLINE
- Journal :
- Molecular and biochemical parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 28818675
- Full Text :
- https://doi.org/10.1016/j.molbiopara.2017.08.003