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Downregulation of MicroRNA-330 Correlates with the Radiation Sensitivity and Prognosis of Patients with Brain Metastasis from Lung Cancer.
- Source :
-
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2017; Vol. 42 (6), pp. 2220-2229. Date of Electronic Publication: 2017 Aug 16. - Publication Year :
- 2017
-
Abstract
- Background: The present study sought to explore the role of microRNA-330 (miR-330) in predicting the radiation response and prognosis of patients with brain metastasis (BM) from lung cancer (LC).<br />Methods: Patients with BM from LC were identified and classified into radiation-sensitive and radiation-resistant groups according to the overall survival rate, local and distant recurrence rate after conventional whole-brain radiation therapy. Quantitative realtime polymerase chain reaction (qRT-PCR) was used to detect miR-330 expression in serum. Receiver operating characteristic (ROC) curves were used to evaluate the prognostic value of miR-330 for the radiation sensitivity of brain metastasis from LC. Related clinical factors for radiation sensitivity were assessed by logistic regression analysis, and a survival analysis was conducted using COX regression and the Kaplan-Meier method.<br />Results: MiR-330 exhibited lower expression in the radiation-sensitive group than in the radiation-resistant group. The area under the ROC curve of miR-330 for predicting radiation sensitivity was 0.898 (optimal cut-off value, 0.815), with a sensitivity of 71.7% and a specificity of 90.1%. After radiation therapy, patients with low miR-330 expression, compared to patients with high miR-330 expression, displayed a lower survival rate and a median survival time. MiR-330 expression was correlated with extracranial metastasis, maximum BM diameter, tumor-node-metastasis (TNM) stage and node (N) stage. Logistic regression and COX regression analyses revealed that extracranial metastasis, TNM stage, N stage and miR-330 expression were factors that influenced both radiation sensitivity and individual prognostic factors in patients with BM from LC.<br />Conclusions: These findings indicate that the downregulation of miR-330 correlates with radiation sensitivity and poor prognosis in patients with BM from LC.<br /> (© 2017 The Author(s). Published by S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Area Under Curve
Biomarkers, Tumor blood
Brain Neoplasms genetics
Brain Neoplasms mortality
Brain Neoplasms secondary
Down-Regulation
Female
Follow-Up Studies
Gamma Rays
Humans
Logistic Models
Male
Middle Aged
Neoplasm Staging
Prognosis
Proportional Hazards Models
ROC Curve
Radiation Tolerance
Brain Neoplasms radiotherapy
Lung Neoplasms pathology
MicroRNAs blood
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9778
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28817811
- Full Text :
- https://doi.org/10.1159/000479996