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Evaluation of incidence, significance, and prognostic role of circulating tumor microemboli and transforming growth factor-β receptor I in head and neck cancer.
- Source :
-
Head & neck [Head Neck] 2017 Nov; Vol. 39 (11), pp. 2283-2292. Date of Electronic Publication: 2017 Aug 17. - Publication Year :
- 2017
-
Abstract
- Background: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-β (TGF-β). The purpose of this study was to verify their role in progression-free survival (PFS).<br />Methods: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n = 53) was analyzed in 2 moments. TGF-β receptor I (TGF-βRI) expression was evaluated by immunocytochemistry.<br />Results: Comparing CTM1 (baseline) with CTM2 (first follow-up), patients with CTM1-positive disease who became CTM2-negative were classified as favorable (PFS 20 months). Patients with unfavorable evolution (CTM1-negative/CTM2-positive), had PFS of 17.5 months. Patients always CTM-negative showed PFS of 22.4 months, those always positive, 4.7 months (P < .001). The TGF-βRI expression in the first follow-up correlated with poor PFS (12 × 26 months; P = .007), being an independent prognostic factor (hazard ratio [HR] = 6.088; P = .033).<br />Conclusion: CTM1/2, TGF-βRI expression, and unfavorable CTM kinetics may represent poor prognosis in locally advanced HNSCC.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Brazil
Carcinoma, Squamous Cell mortality
Cohort Studies
Disease-Free Survival
Female
Head and Neck Neoplasms mortality
Humans
Incidence
Male
Middle Aged
Neoplasm Staging
Proportional Hazards Models
Receptor, Transforming Growth Factor-beta Type I
Squamous Cell Carcinoma of Head and Neck
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms pathology
Neoplastic Cells, Circulating metabolism
Protein Serine-Threonine Kinases metabolism
Receptors, Transforming Growth Factor beta metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 39
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 28815787
- Full Text :
- https://doi.org/10.1002/hed.24899