Back to Search
Start Over
Endoplasmic Reticulum-Mitochondria Communication Through Ca 2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 2017; Vol. 997, pp. 49-67. - Publication Year :
- 2017
-
Abstract
- The execution of proper Ca <superscript>2+</superscript> signaling requires close apposition between the endoplasmic reticulum (ER) and mitochondria. Hence, Ca <superscript>2+</superscript> released from the ER is "quasi-synaptically" transferred to mitochondrial matrix, where Ca <superscript>2+</superscript> stimulates mitochondrial ATP synthesis by activating the tricarboxylic acid (TCA) cycle. However, when the Ca <superscript>2+</superscript> transfer is excessive and sustained, mitochondrial Ca <superscript>2+</superscript> overload induces apoptosis by opening the mitochondrial permeability transition pore. A large number of regulatory proteins reside at mitochondria-associated ER membranes (MAMs) to maintain the optimal distance between the organelles and to coordinate the functionality of both ER and mitochondrial Ca <superscript>2+</superscript> transporters or channels. In this chapter, we discuss the different pathways involved in the regulation of ER-mitochondria Ca <superscript>2+</superscript> flux and describe the activities of the various Ca <superscript>2+</superscript> players based on their primary intra-organelle localization.
- Subjects :
- Animals
Apoptosis
Endoplasmic Reticulum pathology
Energy Metabolism
Humans
Membrane Microdomains pathology
Mitochondria pathology
Mitochondrial Membrane Transport Proteins metabolism
Mitochondrial Membranes pathology
Calcium Signaling
Endoplasmic Reticulum metabolism
Membrane Microdomains metabolism
Membrane Proteins metabolism
Mitochondria metabolism
Mitochondrial Membranes metabolism
Mitochondrial Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 997
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 28815521
- Full Text :
- https://doi.org/10.1007/978-981-10-4567-7_4