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Effects of a new vasodilating beta-blocking drug, carvedilol, on left ventricular function in stable angina pectoris.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1987 Apr 01; Vol. 59 (8), pp. 769-74. - Publication Year :
- 1987
-
Abstract
- The effects of a new vasodilating beta-blocking drug, carvedilol, were studied in 20 patients with chronic stable angina using a single-blind, placebo-controlled protocol. Two doses of carvedilol, 25 mg twice daily and 50 mg twice daily, were compared with placebo using analysis of variance. The study design consisted of 2 weekly phases of initial placebo followed by carvedilol, 25 mg twice daily and then 50 mg twice daily, and a second placebo period. Supine rest and exercise radionuclide ventriculography was performed at the end of each phase. Carvedilol produced a significant dose-related reduction in rest and exercise heart rate and blood pressure (p less than 0.01 to less than 0.0001). Ejection fraction at rest increased significantly, from a mean (+/- standard error) of 53 +/- 3% with placebo to 58 +/- 3% with carvedilol, 50 mg twice daily, but no improvement was noted in ejection fraction on exercise. Relative, counts-based end-systolic and end-diastolic volumes were significantly reduced at rest (p less than 0.001). Rest peak filling rate index, first-third filling fraction and ejection rate index increased significantly with carvedilol. A dose-related change was observed with rest ejection fraction, peak filling rate index and ejection rate index. Exercise-induced ST-segment depression improved significantly with both doses of carvedilol compared with placebo. Carvedilol was well tolerated and produced significant hemodynamic improvement. This salutary effect on left ventricular function may confer advantages in long-term treatment of patients with chronic stable angina.
- Subjects :
- Adrenergic beta-Antagonists adverse effects
Aged
Blood Pressure drug effects
Carbazoles adverse effects
Carvedilol
Electrocardiography
Exercise Test
Female
Heart Rate drug effects
Heart Ventricles diagnostic imaging
Heart Ventricles drug effects
Humans
Male
Middle Aged
Radionuclide Imaging
Vasodilator Agents adverse effects
Adrenergic beta-Antagonists pharmacology
Angina Pectoris physiopathology
Carbazoles pharmacology
Heart drug effects
Propanolamines
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 59
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 2881480
- Full Text :
- https://doi.org/10.1016/0002-9149(87)91089-7