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Non-invasive urinary metabolomic profiling discriminates prostate cancer from benign prostatic hyperplasia.

Non-invasive urinary metabolomic profiling discriminates prostate cancer from benign prostatic hyperplasia.

Authors :
Pérez-Rambla C
Puchades-Carrasco L
García-Flores M
Rubio-Briones J
López-Guerrero JA
Pineda-Lucena A
Source :
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2017; Vol. 13 (5), pp. 52. Date of Electronic Publication: 2017 Mar 09.
Publication Year :
2017

Abstract

Introduction: Prostate cancer (PCa) is one of the most common malignancies in men worldwide. Serum prostate specific antigen (PSA) level has been extensively used as a biomarker to detect PCa. However, PSA is not cancer-specific and various non-malignant conditions, including benign prostatic hyperplasia (BPH), can cause a rise in PSA blood levels, thus leading to many false positive results.<br />Objectives: In this study, we evaluated the potential of urinary metabolomic profiling for discriminating PCa from BPH.<br />Methods: Urine samples from 64 PCa patients and 51 individuals diagnosed with BPH were analysed using <superscript>1</superscript> H nuclear magnetic resonance ( <superscript>1</superscript> H-NMR). Comparative analysis of urinary metabolomic profiles was carried out using multivariate and univariate statistical approaches.<br />Results: The urine metabolomic profile of PCa patients is characterised by increased concentrations of branched-chain amino acids (BCAA), glutamate and pseudouridine, and decreased concentrations of glycine, dimethylglycine, fumarate and 4-imidazole-acetate compared with individuals diagnosed with BPH.<br />Conclusion: PCa patients have a specific urinary metabolomic profile. The results of our study underscore the clinical potential of metabolomic profiling to uncover metabolic changes that could be useful to discriminate PCa from BPH in a clinical context.

Details

Language :
English
ISSN :
1573-3882
Volume :
13
Issue :
5
Database :
MEDLINE
Journal :
Metabolomics : Official journal of the Metabolomic Society
Publication Type :
Academic Journal
Accession number :
28804274
Full Text :
https://doi.org/10.1007/s11306-017-1194-y