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Bevacizumab Plus Radiosurgery for Nonsquamous Non-Small Cell Lung Cancer Patients with Brain Metastases: Safe Combination?
- Source :
-
World neurosurgery [World Neurosurg] 2017 Nov; Vol. 107, pp. 1047.e1-1047.e4. Date of Electronic Publication: 2017 Aug 09. - Publication Year :
- 2017
-
Abstract
- Introduction: In the context of bronchial cancers, the brain is one of the most frequent sites for metastases. Local treatments of these metastases have evolved and are often combined to obtain greater efficiency, while the main objective remains to reduce the symptoms. Radiosurgery is currently used as a primary option for patients harboring few numbers of small to middle-sized brain metastases. In nonsquamous non-small cell lung cancer (NSCLC), chemotherapy is often associated with bevacizumab. Our goal was to assess the safety of this early combination.<br />Clinical Practice Points: Six patients with advanced nonsquamous NSCLC were treated with radiosurgery for the management of their brain metastases (n = 40), followed within <4 weeks by a treatment with bevacizumab. No systemic or cerebral adverse event of grade 3 (intratumoral or parenchymal hemorrhage) or unexpected toxicity secondary to bevacizumab has been indexed.<br />Conclusion: Radiosurgery may be safely combined with bevacizumab quite early on for patients with nonsquamous NSCLC with brain metastases.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Antineoplastic Agents, Immunological adverse effects
Antineoplastic Agents, Immunological therapeutic use
Bevacizumab adverse effects
Brain Neoplasms diagnostic imaging
Carcinoma, Non-Small-Cell Lung diagnostic imaging
Combined Modality Therapy adverse effects
Combined Modality Therapy methods
Female
Humans
Lung Neoplasms diagnostic imaging
Male
Middle Aged
Radiosurgery adverse effects
Bevacizumab therapeutic use
Brain Neoplasms secondary
Brain Neoplasms therapy
Carcinoma, Non-Small-Cell Lung therapy
Lung Neoplasms therapy
Radiosurgery methods
Subjects
Details
- Language :
- English
- ISSN :
- 1878-8769
- Volume :
- 107
- Database :
- MEDLINE
- Journal :
- World neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 28803179
- Full Text :
- https://doi.org/10.1016/j.wneu.2017.07.185