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Variant histology, IgD and CD30 expression in low-risk pediatric nodular lymphocyte predominant Hodgkin lymphoma: A report from the Children's Oncology Group.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2018 Jan; Vol. 65 (1). Date of Electronic Publication: 2017 Aug 12. - Publication Year :
- 2018
-
Abstract
- Background: Histologic prognostic factors have been described for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). This study examines histologic and immunophenotypic variants in a clinical trial for pediatric NLPHL.<br />Procedure: One hundred sixty-eight cases of localized NLPHL were examined for histologic variants, CD30 and immunoglobulin D (IgD) expression, and outcome. Histologic types were scored categorically as 0 = 0, 1 ≤ 25%, and 2 > 25% of the sample.<br />Results: Fifty-eight (35.1%) cases showed only typical nodular with or without serpiginous histology (types A and B). The remainder showed mixtures of histologies. The numbers of patients with score 2 are 85 (50.6%) type A, 21 (12.5%) type B, 46 (27.4%) with extranodular large B cells (type C), 3 with T-cell-rich nodular pattern (type D), 55 (32.7%) with diffuse T-cell-rich (type E) pattern, and 2 (1.2%) with diffuse B-cell pattern (type F). Higher level of types C (P = 0.048) and D (P = 0.033) resulted in lower event-free survival (EFS). Cytoplasmic IgD was found in 65 of 130 tested (50%), did not significantly associate with EFS but positively correlated with types C and E histology (P < 0.0001) and negatively correlated with types A (P = 0.0003) and B (P = 0.006). Seventeen (10%) expressed CD30, with no adverse effect.<br />Conclusions: Variant histology is common in pediatric NLPHL, especially types C and E, which are associated with IgD expression. Type C variant histology and possibly type D are associated with decreased EFS, but neither IgD nor CD30 are adverse features. Variant histology may warrant increased surveillance, but did not affect overall survival.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Child
Child, Preschool
Disease-Free Survival
Female
Humans
Immunohistochemistry
Infant
Infant, Newborn
Male
Survival Rate
B-Lymphocytes metabolism
B-Lymphocytes pathology
Gene Expression Regulation, Neoplastic
Hodgkin Disease metabolism
Hodgkin Disease mortality
Hodgkin Disease pathology
Immunoglobulin D biosynthesis
Ki-1 Antigen biosynthesis
T-Lymphocytes metabolism
T-Lymphocytes pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 65
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 28802087
- Full Text :
- https://doi.org/10.1002/pbc.26753