Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum.

Authors :: Huang SZ
Ma QY
Kong FD
Guo ZK
Cai CH
Hu LL
Zhou LM
Wang Q
Dai HF
Mei WL
Zhao YX
Source :: Phytochemistry [Phytochemistry] 2017 Nov; Vol. 143, pp. 104-110. Date of Electronic Publication: 2017 Aug 08.
Publication Year :: 2017
Abstract: To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC <subscript>50</subscript> values of 7.62, 6.28, and 3.55 μM, respectively.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)