Impact of oral gut decontamination on Staphylococcus aureus colonisation in patients undergoing allogeneic haematopoietic stem cell transplantation.

Authors :: Wilk CM
Weber I
Seidl K
Rachmühl C
Holzmann-Bürgel A
Müller AMS
Kuster SP
Schanz U
Zinkernagel AS
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2017 Dec; Vol. 50 (6), pp. 726-729. Date of Electronic Publication: 2017 Aug 07.
Publication Year :: 2017
Abstract: Recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) are severely immunocompromised and are at increased risk of infection. In this prospective, observational, single-centre study including 110 allo-HSCT recipients, the rate of Staphylococcus aureus colonisation was reduced from 11.8% to 0% (P <0.001) following peritransplant oral gut decontamination. No invasive S. aureus infections were observed.<br /> (Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.)

Subjects :: Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Immunocompromised Host
Male
Middle Aged
Prospective Studies
Transplantation, Homologous
Treatment Outcome
Young Adult
Decontamination methods
Gastrointestinal Tract microbiology
Hematopoietic Stem Cell Transplantation
Mouth microbiology
Staphylococcal Infections drug therapy

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