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Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Aug 09. Date of Electronic Publication: 2017 Aug 09. - Publication Year :
- 2017
- Publisher :
- Ahead of Print
-
Abstract
- Sustained Ca <superscript>2+</superscript> signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8 <superscript>+</superscript> T cells require sustained Ca <superscript>2+</superscript> signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca <superscript>2+</superscript> signaling to murine NK cell function. Surprisingly, we found that, although SOCE is required for NK cell IFN-γ production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo remained intact in the absence of sustained Ca <superscript>2+</superscript> signaling. Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.<br /> (Copyright © 2017 by The American Association of Immunologists, Inc.)
Details
- Language :
- English
- ISSN :
- 1550-6606
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 28794231
- Full Text :
- https://doi.org/10.4049/jimmunol.1700340