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Use of endocytoscopy for identification of sessile serrated adenoma/polyps and hyperplastic polyps by quantitative image analysis of the luminal areas.
Use of endocytoscopy for identification of sessile serrated adenoma/polyps and hyperplastic polyps by quantitative image analysis of the luminal areas.
- Source :
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Endoscopy international open [Endosc Int Open] 2017 Aug; Vol. 5 (8), pp. E769-E774. Date of Electronic Publication: 2017 Aug 07. - Publication Year :
- 2017
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Abstract
- Background and Study Aims: Recent studies that used magnifying chromoendoscopy and endocytoscopy (EC) to investigate endoscopic features of sessile serrated adenoma/polyps (SSA/Ps) suggested that a dilated crypt opening was an important indicator of SSA/Ps. However, no studies to date have measured the actual extent of dilatation. Hence, we investigated retrospectively the luminal areas using EC to determine a cutoff value for differentiating SSA/Ps from hyperplastic polyps (HPs).<br />Patients and Methods: A total of 101 lesions, including 25 SSA/Ps, 66 HPs, and 10 normal mucosal samples, assessed by an integrated-type EC were collected. For each lesion, 1 image that showed the widest lumen was selected and the average area of the contiguous 3 lumens were calculated. The cutoff value differentiating SSAPs from HPs was determined by receiver operating curve (ROC) analysis.<br />Results: The mean luminal areas of SSA/Ps and HPs were 4152 μm <superscript>2</superscript> and 2117 μm <superscript>2</superscript> , respectively. ROC analysis found that a luminal area cutoff of 3068 μm <superscript>2</superscript> had a sensitivity of 80.0 %, a specificity of 77.3 %, an accuracy of 78.0 %, and an area under the ROC curve of 0.865. Furthermore, a cutoff of ≥ 556 μm <superscript>2</superscript> was found to accurately distinguish between HPs and normal mucosa (sensitivity 98.5 %, specificity 100 %, accuracy 98.7 %, and AUC 0.998).<br />Conclusions: EC analysis of the luminal area is useful for differentiating between SSAPs and HPs. This approach could be adapted for computer-aided diagnosis of SSA/P.
Details
- Language :
- English
- ISSN :
- 2364-3722
- Volume :
- 5
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Endoscopy international open
- Publication Type :
- Academic Journal
- Accession number :
- 28791327
- Full Text :
- https://doi.org/10.1055/s-0043-113562