Back to Search
Start Over
Role of domestic ducks in the emergence of a new genotype of highly pathogenic H5N1 avian influenza A viruses in Bangladesh.
- Source :
-
Emerging microbes & infections [Emerg Microbes Infect] 2017 Aug 09; Vol. 6 (8), pp. e72. Date of Electronic Publication: 2017 Aug 09. - Publication Year :
- 2017
-
Abstract
- Highly pathogenic avian influenza H5N1 viruses were first isolated in Bangladesh in February 2007. Subsequently, clades 2.2.2, 2.3.4.2 and 2.3.2.1a were identified in Bangladesh, and our previous surveillance data revealed that by the end of 2014, the circulating viruses exclusively comprised clade 2.3.2.1a. We recently determined the status of circulating avian influenza viruses in Bangladesh by conducting surveillance of live poultry markets and waterfowl in wetland areas from February 2015 through February 2016. Until April 2015, clade 2.3.2.1a persisted without any change in genotype. However, in June 2015, we identified a new genotype of H5N1 viruses, clade 2.3.2.1a, which quickly became predominant. These newly emerged H5N1 viruses contained the hemagglutinin, neuraminidase and matrix genes of circulating 2.3.2.1a Bangladeshi H5N1 viruses and five other genes of low pathogenic Eurasian-lineage avian influenza A viruses. Some of these internal genes were closely related to those of low pathogenic viruses isolated from ducks in free-range farms and wild birds in a wetland region of northeastern Bangladesh, where commercially raised domestic ducks have frequent contact with migratory birds. These findings indicate that migratory birds of the Central Asian flyway and domestic ducks in the free-range farms in Tanguar haor-like wetlands played an important role in the emergence of this novel genotype of highly pathogenic H5N1 viruses.
- Subjects :
- Animal Migration
Animals
Animals, Wild virology
Anseriformes virology
Bangladesh epidemiology
Ducks virology
Epidemiological Monitoring
Genotype
Hemagglutinin Glycoproteins, Influenza Virus genetics
Influenza A Virus, H5N1 Subtype classification
Influenza in Birds epidemiology
Influenza in Birds transmission
Neuraminidase genetics
Poultry Diseases epidemiology
Poultry Diseases transmission
Reassortant Viruses genetics
Viral Matrix Proteins genetics
Wetlands
Influenza A Virus, H5N1 Subtype genetics
Influenza A Virus, H5N1 Subtype pathogenicity
Influenza in Birds virology
Poultry Diseases virology
Subjects
Details
- Language :
- English
- ISSN :
- 2222-1751
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Emerging microbes & infections
- Publication Type :
- Academic Journal
- Accession number :
- 28790460
- Full Text :
- https://doi.org/10.1038/emi.2017.60