Back to Search
Start Over
Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 2017; Vol. 173 (3), pp. 138-146. Date of Electronic Publication: 2017 Aug 09. - Publication Year :
- 2017
-
Abstract
- Background: The order Fagales represents an important cause of tree-pollen allergy in northern countries. We investigated the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR-10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1).<br />Methods: A total of 526 PR-10-reactive subjects living in central and southern Italy were studied by ImmunoCAP-ISAC-112 microarray analysis.<br />Results: Overall, Bet v 1 reactivity was the most commonly (74%) observed among PR-10 proteins, but Cor a 1.0101 was the most prevalent in participants aged <6 years, and between 15 and 65 years. Overall, 26% of the PR-10-reactive persons were Bet v 1 negative, whilst 93.6% of the PR-10 polyreactive individuals were Bet v 1 positive. Among the 10 PR-10s evaluated, 100 combinations were recorded. The strongest association was observed between molecules with the highest sequence identities (Bet v 1 and Cor a 1.0101, Cor a 1.0401 or Aln g 1; Mal d 1 and Pru p 1). Bet v 1-, Cor a 1.0101-, and Aln g 1-specific IgE recognition was associated with respiratory symptoms, whilst Ara h 8, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1 were selectively linked to an oral allergic syndrome.<br />Conclusions: Testing IgE reactivity to a panel of PR-10s in a birch-free area discloses peculiar relationships between clinical phenotypes and sensitization profiles, allowing the identification of novel cluster patterns.<br /> (© 2017 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Betula
Child
Child, Preschool
Female
Humans
Hypersensitivity diagnosis
Immunoglobulin E immunology
Infant
Italy
Male
Middle Aged
Young Adult
Allergens immunology
Antigens, Plant immunology
Hypersensitivity blood
Immunoglobulin E blood
Plant Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0097
- Volume :
- 173
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28787736
- Full Text :
- https://doi.org/10.1159/000477565