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New asymmetrical bispyrrolidinoindoline diketopiperazines from the marine fungus Aspergillus sp. DX4H.
- Source :
-
Natural product research [Nat Prod Res] 2018 Apr; Vol. 32 (7), pp. 815-820. Date of Electronic Publication: 2017 Aug 08. - Publication Year :
- 2018
-
Abstract
- Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1-3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey's method. Their inhibitory activity against PC3 cell line had been tested.
- Subjects :
- Antineoplastic Agents chemistry
Aquatic Organisms
Aspergillus genetics
Cell Line, Tumor
Circular Dichroism
Drug Screening Assays, Antitumor
Fermentation
Humans
Indoles isolation & purification
Magnetic Resonance Spectroscopy
Male
Molecular Structure
Piperazines isolation & purification
Prostatic Neoplasms drug therapy
Prostatic Neoplasms pathology
Spectrometry, Mass, Electrospray Ionization
Stereoisomerism
Antineoplastic Agents pharmacology
Aspergillus chemistry
Indoles chemistry
Indoles pharmacology
Piperazines chemistry
Piperazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 28786310
- Full Text :
- https://doi.org/10.1080/14786419.2017.1363752