Back to Search
Start Over
Genetic transmission networks reveal the transmission patterns of HIV-1 CRF01_AE in China.
- Source :
-
Sexually transmitted infections [Sex Transm Infect] 2018 Mar; Vol. 94 (2), pp. 111-116. Date of Electronic Publication: 2017 Aug 07. - Publication Year :
- 2018
-
Abstract
- Objectives: The epidemic of HIV-1 CRF01&#95;AE has become a major public health issue in China. This study aimed to characterise the transmission patterns of genetic networks for CRF01&#95;AE nationwide and elucidate possible opportunities for prevention.<br />Methods: We isolated and conducted genetic transmission network analysis of all available CRF01&#95;AE pol sequences (n=4704) from China in the Los Alamos HIV sequence database.<br />Results: A total of 1391 (29.6%) sequences were identified as belonging to 400 separate networks. Of men who have sex with men (MSM) in the networks, 93.8% were linked to other MSM and only 2.4% were linked to heterosexual women. However, 11.8% heterosexual women in the networks were linked to MSM. Lineages composed mainly of MSM had higher transmission than those that were mostly heterosexuals. Of the 1391 individuals in networks, 513 (36.9%) were linked to cases diagnosed in different provinces. The proportion of individuals involved in inter-province links was interrelated with the number of migrant people (Spearman's r =0.738, p =0.001).<br />Conclusions: The outcome of this study could help improve our ability to understand HIV transmission among various regions and risk groups in China, and highlighted the importance of targeting MSM and migrants by prevention and intervention efforts.<br />Competing Interests: Competing interests: None declared.<br /> (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Subjects :
- Adult
China epidemiology
Epidemics prevention & control
Female
HIV Infections epidemiology
HIV Infections prevention & control
HIV Infections virology
HIV-1 classification
HIV-1 isolation & purification
Heterosexuality statistics & numerical data
Homosexuality, Male statistics & numerical data
Humans
Male
Middle Aged
Phylogeny
RNA, Viral genetics
Risk Factors
Young Adult
Gene Regulatory Networks
HIV Infections transmission
HIV-1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1472-3263
- Volume :
- 94
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Sexually transmitted infections
- Publication Type :
- Academic Journal
- Accession number :
- 28784618
- Full Text :
- https://doi.org/10.1136/sextrans-2016-053085