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Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect.
- Source :
-
Fitoterapia [Fitoterapia] 2017 Sep; Vol. 121, pp. 206-211. Date of Electronic Publication: 2017 Aug 01. - Publication Year :
- 2017
-
Abstract
- Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium nobile Lindl. Their structures were established by spectroscopic analyses and physical properties. Compound 1 was a new dendrobine analogue. Although the planar structure of 2 and 3 had been reported, their absolute configurations were first determined by single-crystal X-ray diffraction and circular dichroism. Compound 2 exhibited angiogenesis effect against sunitinib-induced damage on intersegmental blood vessels in Tg (flk1: EGFP) and Tg (fli1: nEGFP) transgenic zebrafish at concentrations of 3.13, 6.25, 12.50, and 25.00μM.<br /> (Copyright © 2017. Published by Elsevier B.V.)
- Subjects :
- Alkaloids isolation & purification
Angiogenesis Inducing Agents isolation & purification
Animals
Animals, Genetically Modified
Molecular Structure
Plant Stems chemistry
Sesquiterpenes isolation & purification
Zebrafish
Alkaloids pharmacology
Angiogenesis Inducing Agents pharmacology
Dendrobium chemistry
Sesquiterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 121
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 28778562
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.07.017