Updated meta-analysis of CMYA5 rs3828611 and rs4704591 with schizophrenia in Asian populations.

Authors :: Hoya S
Watanabe Y
Shibuya M
Someya T
Source :: Early intervention in psychiatry [Early Interv Psychiatry] 2018 Oct; Vol. 12 (5), pp. 938-941. Date of Electronic Publication: 2017 Aug 04.
Publication Year :: 2018
Abstract: Aim: Two single-nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy-associated protein 5 (CMYA5) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta-analysis.<br />Methods: We performed a random-effect model meta-analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case-control samples from Asian populations (8074 patients and 8139 controls).<br />Results: The meta-analysis indicated that rs3828611 and rs4704591 were not significantly associated with schizophrenia (odds ratios [OR] = 0.93, 95% confidence interval [CI] = 0.85-1.01 and OR = 0.99, 95% CI = 0.93-1.05, respectively).<br />Conclusions: Our meta-analysis did not provide evidence supporting a contribution of CMYA5 rs3828611 and rs4704591 to schizophrenia susceptibility in Asian populations.<br /> (© 2017 John Wiley & Sons Australia, Ltd.)

Subjects :: Case-Control Studies
Humans
Asian People genetics
Genetic Predisposition to Disease genetics
Muscle Proteins genetics
Polymorphism, Single Nucleotide genetics
Schizophrenia genetics

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