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Crystal structures of 2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]- N -(2,4-di-methyl-phen-yl)acetamide and 2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]- N -(3-meth-oxy-phen-yl)acetamide.
- Source :
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Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2017 Jun 13; Vol. 73 (Pt 7), pp. 996-1000. Date of Electronic Publication: 2017 Jun 13 (Print Publication: 2017). - Publication Year :
- 2017
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Abstract
- In the title compounds, C <subscript>14</subscript> H <subscript>17</subscript> N <subscript>5</subscript> OS (I) and C <subscript>13</subscript> H <subscript>15</subscript> N <subscript>5</subscript> O <subscript>2</subscript> S (II), the dihedral angle between the pyrimidine and benzene rings is 58.64 (8)° in (I) and 78.33 (9)° in (II). In both compounds, there is an intra-molecular C-H⋯O hydrogen bond, and in (II) there is also an intra-molecular N-H⋯N hydrogen bond present. In the crystals of both compounds, a pair of N-H⋯N hydrogen bonds links the individual mol-ecules to form inversion dimers with R <subscript>2</subscript> <superscript>2</superscript> (8) ring motifs. In (I), the dimers are linked by N-H⋯O and C-H⋯O hydrogen bonds, enclosing R <subscript>2</subscript> <superscript>1</superscript> (14), R <subscript>2</subscript> <superscript>1</superscript> (11) and R <subscript>2</subscript> <superscript>1</superscript> (7) ring motifs, forming layers parallel to the (100) plane. There is also an N-H⋯π inter-action present within the layer. In (II), the inversion dimers are linked by N-H⋯O hydrogen bonds enclosing an R <subscript>4</subscript> <superscript>4</superscript> (18) ring motif. The presence of N-H⋯O and C-H⋯O hydrogen bonds generate an R <subscript>2</subscript> <superscript>1</superscript> (6) ring motif. The combination of these various hydrogen bonds results in the formation of layers parallel to the (1-11) plane.
Details
- Language :
- English
- ISSN :
- 2056-9890
- Volume :
- 73
- Issue :
- Pt 7
- Database :
- MEDLINE
- Journal :
- Acta crystallographica. Section E, Crystallographic communications
- Publication Type :
- Academic Journal
- Accession number :
- 28775869
- Full Text :
- https://doi.org/10.1107/S2056989017008143