Back to Search
Start Over
Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells.
- Source :
-
Science (New York, N.Y.) [Science] 2017 Aug 25; Vol. 357 (6353), pp. 806-810. Date of Electronic Publication: 2017 Aug 03. - Publication Year :
- 2017
-
Abstract
- The small intestine contains CD4 <superscript>+</superscript> CD8αα <superscript>+</superscript> double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4 <superscript>+</superscript> T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence of Lactobacillus reuteri This species induced DP IELs in germ-free mice and conventionally-raised mice lacking these cells. L. reuteri did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor in CD4 <superscript>+</superscript> T cells, allowing Thpok down-regulation and differentiation into DP IELs. Thus, L. reuteri , together with a tryptophan-rich diet, can reprogram intraepithelial CD4 <superscript>+</superscript> T cells into immunoregulatory T cells.<br /> (Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors metabolism
Down-Regulation
Germ-Free Life
Indoles metabolism
Intestinal Mucosa immunology
Intestinal Mucosa microbiology
Mice
Mice, Inbred C57BL
Receptors, Aryl Hydrocarbon metabolism
Transcription Factors metabolism
Tryptophan metabolism
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Gastrointestinal Microbiome immunology
Intestine, Small immunology
Intestine, Small microbiology
Limosilactobacillus reuteri immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 357
- Issue :
- 6353
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 28775213
- Full Text :
- https://doi.org/10.1126/science.aah5825