Paradoxical activation of alternative pro-survival pathways determines resistance to MEK inhibitors in chronic lymphocytic leukaemia.

Authors :: Chen Y
Germano S
Shelmani G
Kluczna D
Jayne S
Dyer MJS
Macip S
Source :: British journal of haematology [Br J Haematol] 2018 Sep; Vol. 182 (6), pp. 921-924. Date of Electronic Publication: 2017 Aug 02.
Publication Year :: 2018

Subjects :: Humans
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors pharmacology
Signal Transduction
Tumor Cells, Cultured
raf Kinases metabolism
Drug Resistance, Neoplasm
Leukemia, Lymphocytic, Chronic, B-Cell metabolism
MAP Kinase Signaling System drug effects

Full Text Access

Tools