miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential.

Authors :: Solé C
Larrea E
Di Pinto G
Tellaetxe M
Lawrie CH
Source :: Cancer letters [Cancer Lett] 2017 Oct 01; Vol. 405, pp. 79-89. Date of Electronic Publication: 2017 Jul 27.
Publication Year :: 2017
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)