(+) or (-)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review.

Authors :: Moldovan RC
Bodoki E
Servais AC
Crommen J
Oprean R
Fillet M
Source :: Journal of chromatography. A [J Chromatogr A] 2017 Sep 01; Vol. 1513, pp. 1-17. Date of Electronic Publication: 2017 Jul 16.
Publication Year :: 2017
Abstract: Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related to the state of the art in FLEC labeling and subsequent chiral separation of the resulting diastereomers using LC, SFC and CE techniques.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: Amino Acids isolation & purification
Buffers
Hydrogen-Ion Concentration
Indicators and Reagents
Molecular Structure
Peptides isolation & purification
Stereoisomerism
Chromatography, High Pressure Liquid methods
Electrophoresis, Capillary methods
Fluorenes chemistry
Mass Spectrometry methods
Solid Phase Extraction methods

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