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Single oral dose of cannabinoid derivate loaded PLGA nanocarriers relieves neuropathic pain for eleven days.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2017 Nov; Vol. 13 (8), pp. 2623-2632. Date of Electronic Publication: 2017 Jul 26. - Publication Year :
- 2017
-
Abstract
- Neuropathic pain, resistant to opiates and other drugs, is a chronic/persistent state with a complex treatment and often poor efficacy. In this scenario, cannabinoids are increasingly regarded as a genuine alternative. In this paper, and in an experimental animal model of neuropathic pain, we studied the efficacy of three kinds of PLGA nanoparticles containing synthetic cannabinoid CB13: (i) plain nanoparticles (PLGA); (ii) particles coated with PEG chains (PLGA+PEG) and (iii) particles possessing hydrophilic surfaces obtained by covalently binding PEG chains (PLGA-PEG). The optimized formulation, CB13-PLGA-PEG, showed high drug loading (13%) and small size (<300nm) with a narrow distribution and controlled surface properties (near-neutral zeta potential and stable PEG corona). Animal nociceptive behavioral studies were conducted by paw pressure and acetone tests. Versus the free CB13, CB13-PLGA-PEG nanoparticles showed a very noticeable analgesic efficacy with the longest sustained pain-relieving effect, lasting up to eleven days after one oral dose.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Analgesics therapeutic use
Animals
Cannabinoid Receptor Agonists therapeutic use
Dogs
Lactic Acid chemistry
Male
Nanoparticles chemistry
Naphthalenes therapeutic use
Polyglycolic Acid chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Rats, Sprague-Dawley
Analgesics administration & dosage
Cannabinoid Receptor Agonists administration & dosage
Drug Carriers chemistry
Naphthalenes administration & dosage
Neuralgia drug therapy
Polyesters chemistry
Polyethylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28756090
- Full Text :
- https://doi.org/10.1016/j.nano.2017.07.010