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Epithelioid sarcomas: How important is loco-regional control?
- Source :
-
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2017 Sep; Vol. 43 (9), pp. 1746-1752. Date of Electronic Publication: 2017 Jul 19. - Publication Year :
- 2017
-
Abstract
- Aims: To investigate the impact of the method of treatment on the oncological outcomes in patients with epithelioid sarcomas managed at two international speciality sarcoma centres.<br />Methods: The databases of two centres were used to identify patients treated for epithelioid sarcomas between 1985 and 2012. Patient, tumor, treatment and outcome data was collected.<br />Results: There were 36 males and 18 females with a mean age of 38.3 years (range 9-79). Of 49 patients who were treated surgically, limb salvage surgery was carried out in 38 patients (78%) and limb amputation in 11 (22%). Of 49 total patients who underwent surgery for ES, 48 (98%) with ES had negative margin resection and 24 (49%) received (neo) adjuvant radiotherapy. Regional lymph node metastases developed in 5 (13%) patients. The five-year risk of local recurrence was 14%. The overall survival rate at five and ten years was 70% and 66% respectively. In multivariate analysis of patients with localized disease and negative margins, survival and risk of metastases was worse in those treated by amputation.<br />Conclusion: This series has shown that although the rate of local recurrence is not influenced by the type of surgery, the risk of metastases is higher following amputation. This finding is likely due to patients with larger, deeper and more locally advanced tumors requiring amputation. However, we could not prove that immediate amputation was likely to affect overall survival.<br /> (Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Child
Disease-Free Survival
Extremities
Female
Humans
Lymphatic Metastasis
Male
Margins of Excision
Middle Aged
Neoplasm, Residual
Radiotherapy, Adjuvant
Retrospective Studies
Sarcoma radiotherapy
Sarcoma secondary
Survival Rate
Tumor Burden
Young Adult
Amputation, Surgical
Neoplasm Recurrence, Local
Organ Sparing Treatments
Sarcoma surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2157
- Volume :
- 43
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28756018
- Full Text :
- https://doi.org/10.1016/j.ejso.2017.07.002