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Treatment of larva migrans syndrome with long-term administration of albendazole.
- Source :
-
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2019 Feb; Vol. 52 (1), pp. 100-105. Date of Electronic Publication: 2017 Jul 14. - Publication Year :
- 2019
-
Abstract
- Background: Larva migrans syndrome is a food-borne parasitic disease in humans, caused by accidental ingestion of eggs or larvae of ascarid nematodes, namely, Toxocara canis, Toxocara cati, or Ascaris suum, the roundworms commonly found in the intestines of dogs, cats and pigs respectively. When a patient is diagnosed as having larva migrans syndrome, oral-administration of albendazole is recommended, however, the regimen remains controversial worldwide. In Japan, the duration of albendazole administration is longer than those of European and North American countries. The purpose of this study was to assess the efficacy and safety of long-term administration treatment of albendazole for larva migrans syndrome.<br />Methods: From 2004 to 2014, our laboratory was involved in the diagnosis of 758 larva migrans syndrome cases, of which 299 cases could be followed up after the treatment. We analyzed these 299 follow-up cases on the ELISA results before and after the treatment as well as on anthelmintic used, dose and duration of medication, clinical findings, and side effects, recorded on a consultation sheet provided by the attending physicians. We have 288 cases as the subjects of this study.<br />Results: Albendazole represented a 78.0% efficacy rate. The side effects represented 15.0% in using albendazole alone cases; however, the side effects were mild to moderate and there were no severe cases reported.<br />Conclusions: The long-term administration treatment of albendazole is safe and effective for larva migrans syndrome.<br /> (Copyright © 2017. Published by Elsevier B.V.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Albendazole adverse effects
Animals
Anthelmintics adverse effects
Antibodies, Helminth analysis
Ascaridoidea immunology
Child
Female
Follow-Up Studies
Humans
Japan
Larva immunology
Male
Middle Aged
Treatment Outcome
Young Adult
Albendazole therapeutic use
Anthelmintics therapeutic use
Larva Migrans drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1995-9133
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 28754237
- Full Text :
- https://doi.org/10.1016/j.jmii.2017.07.002