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New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis.
- Source :
-
Trends in parasitology [Trends Parasitol] 2017 Sep; Vol. 33 (9), pp. 662-664. Date of Electronic Publication: 2017 Jul 24. - Publication Year :
- 2017
-
Abstract
- The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cattle
Cattle Diseases drug therapy
Cryptosporidium drug effects
Dehydration drug therapy
Dehydration etiology
Humans
Immunocompromised Host
Mice
Pyrazoles pharmacology
Pyridines pharmacology
Cryptosporidiosis complications
Cryptosporidiosis drug therapy
Diarrhea drug therapy
Diarrhea etiology
Pyrazoles therapeutic use
Pyridines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1471-5007
- Volume :
- 33
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Trends in parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 28750950
- Full Text :
- https://doi.org/10.1016/j.pt.2017.07.004