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Caffeine decreases intermittent hypoxia in preterm infants nearing term-equivalent age.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2017 Oct; Vol. 37 (10), pp. 1135-1140. Date of Electronic Publication: 2017 Jul 27. - Publication Year :
- 2017
-
Abstract
- Objective: To determine whether intermittent hypoxia (IH) persisting after 36 weeks postmenstrual age (PMA) can be attenuated using caffeine doses sufficient to maintain caffeine concentrations >20 μg ml <superscript>-1</superscript> .<br />Study Design: Twenty-seven infants born <32 weeks were started on caffeine citrate at 10 mg kg <superscript>-1</superscript> day <superscript>-1</superscript> when clinical caffeine was discontinued. At 36 weeks PMA, the dose was increased to 14 or 20 mg kg <superscript>-1</superscript> day <superscript>-1</superscript> divided twice a day (BID) to compensate for progressively increasing caffeine metabolism. Caffeine concentrations were measured weekly. The extent of IH derived from continuous pulse oximetry was compared to data from 53 control infants.<br />Result: The mean (s.d.) gestational age of enrolled infants was 27.9±2 weeks. Median caffeine levels were >20 μg ml <superscript>-1</superscript> on study caffeine doses. IH was significantly attenuated through 38 weeks PMA compared with the control group.<br />Conclusion: Caffeine doses of 14 to 20 mg kg <superscript>-1</superscript> day <superscript>-1</superscript> were sufficient to maintain caffeine concentrations >20 μg ml <superscript>-1</superscript> and reduce IH in preterm infants at 36 to 38 weeks PMA.
- Subjects :
- Adult
Caffeine analysis
Caffeine metabolism
Case-Control Studies
Central Nervous System Stimulants analysis
Central Nervous System Stimulants metabolism
Citrates analysis
Citrates metabolism
Drug Administration Schedule
Female
Gestational Age
Humans
Hypoxia epidemiology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases epidemiology
Male
Oximetry
Prospective Studies
Caffeine administration & dosage
Central Nervous System Stimulants administration & dosage
Citrates administration & dosage
Hypoxia prevention & control
Infant, Premature, Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 37
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 28749480
- Full Text :
- https://doi.org/10.1038/jp.2017.82