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Randomized crossover study investigating daily versus on-demand vulvar Visnadine spray in women affected by female sexual arousal disorder.
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2018 Feb; Vol. 34 (2), pp. 110-114. Date of Electronic Publication: 2017 Jul 27. - Publication Year :
- 2018
-
Abstract
- The aim of the study was to verify the efficacy of vulvar Visnadine spray in premenopausal women affected by female sexual arousal disorder (FSAD). Thirty-eight women aged 25-40 years affected by FSAD were enrolled in the randomized crossover study, by two possible sequences: on-demand, washout, daily (A sequence); and daily, washout, on-demand (B sequence). The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess sexual function and sexual distress, respectively. Color Doppler ultrasonography was used to measure clitoral blood flow. The study had two follow-ups at 30 (T1) and 60 days (T2). Thirty-one women completed the study. Mean (SD) sexual activity and vulvar Visnadine spray usage was 1 ± 0.9 weekly during on-demand administration for both the sequences (Vs T0, p = NS). The mean sexual activity during daily usage was 2 ± 0.9 (Vs T0, p < .004) and 2 ± 0.8 (Vs T0, p < .001) for A and B sequences, respectively. FSFI total score, particularly genital arousal, improved more during the daily than during on-demand phases of both sequences (p < .001). Finally, clitoral blood flow improved significantly during daily usage of both the sequences (p < .001). Our study suggests that vulvar Visnadine spray could improve sexual performance of women affected by FSAD, producing changes in subjective and objective sexual aspects.
- Subjects :
- Administration, Cutaneous
Administration, Mucosal
Adult
Aerosols
Chromans administration & dosage
Clitoris blood supply
Clitoris drug effects
Clitoris physiopathology
Clitoris surgery
Cross-Over Studies
Diagnostic and Statistical Manual of Mental Disorders
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Patient Dropouts
Psychiatric Status Rating Scales
Regional Blood Flow drug effects
Sexual Dysfunction, Physiological etiology
Sexual Dysfunction, Physiological psychology
Stress, Psychological etiology
Stress, Psychological prevention & control
Ultrasonography, Doppler, Color
Vagina blood supply
Vagina metabolism
Vagina physiopathology
Vaginal Diseases diagnostic imaging
Vaginal Diseases physiopathology
Vasodilator Agents administration & dosage
Vulva blood supply
Vulva metabolism
Vulva physiopathology
Vulvar Diseases diagnostic imaging
Vulvar Diseases physiopathology
Chromans therapeutic use
Sexual Dysfunction, Physiological prevention & control
Vagina drug effects
Vaginal Diseases drug therapy
Vasodilator Agents therapeutic use
Vulva drug effects
Vulvar Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 28749253
- Full Text :
- https://doi.org/10.1080/09513590.2017.1354366