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One-pot synthesis of three-dimensional Mn 3 O 4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole.
- Source :
-
Journal of colloid and interface science [J Colloid Interface Sci] 2017 Nov 01; Vol. 505, pp. 1193-1201. Date of Electronic Publication: 2017 Jul 04. - Publication Year :
- 2017
-
Abstract
- We described a three-dimensional Mn <subscript>3</subscript> O <subscript>4</subscript> microcubes (3D-Mn <subscript>3</subscript> O <subscript>4</subscript> MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn <subscript>3</subscript> O <subscript>4</subscript> MCs possess large active area and high conductivity, and 3D-Mn <subscript>3</subscript> O <subscript>4</subscript> MCs film modified screen-printed carbon electrode (3D-Mn <subscript>3</subscript> O <subscript>4</subscript> MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025-8060µM concentration range and the detection limit was 6nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1095-7103
- Volume :
- 505
- Database :
- MEDLINE
- Journal :
- Journal of colloid and interface science
- Publication Type :
- Academic Journal
- Accession number :
- 28738516
- Full Text :
- https://doi.org/10.1016/j.jcis.2017.07.006