Back to Search
Start Over
Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Sep 16; Vol. 491 (2), pp. 374-381. Date of Electronic Publication: 2017 Jul 17. - Publication Year :
- 2017
-
Abstract
- While some long noncoding RNAs (lncRNAs) might promote nasopharyngeal carcinoma (NPC) initiation and progression, the involved molecular mechanisms remain largely unclear. Here, we discovered the novel LncRNA, prostate cancer associated transcript 7 (PCAT7), which was overexpressed and associated with worse prognosis in NPC. Decreased PCAT7 expression was found to significantly suppress tumor cell proliferation in vitro, and inhibited tumor growth and reduced the expression of proliferation antigen Ki-67 in vivo. Rescue assay was performed to further confirm that PCAT7 contributed to the progression of NPC through regulating miR-134-5p/ELF2 signal pathway. These results indicated that PCAT7 might contribute to the tumor progression in NPC by functioning as a ceRNA to sponge miR-134-5p.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Base Sequence
Binding Sites
Carcinogenesis
Carcinoma mortality
Carcinoma pathology
Cell Line, Tumor
Cell Proliferation
Cell Survival
Genes, Reporter
Humans
Ki-67 Antigen genetics
Ki-67 Antigen metabolism
Luciferases genetics
Luciferases metabolism
MicroRNAs metabolism
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms mortality
Nasopharyngeal Neoplasms pathology
Prognosis
RNA, Long Noncoding metabolism
Signal Transduction
Survival Analysis
Transcription Factors metabolism
Carcinoma diagnosis
Carcinoma genetics
Gene Expression Regulation, Neoplastic
MicroRNAs genetics
Nasopharyngeal Neoplasms diagnosis
Nasopharyngeal Neoplasms genetics
RNA, Long Noncoding genetics
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 491
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 28728844
- Full Text :
- https://doi.org/10.1016/j.bbrc.2017.07.093