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Second generation drug-eluting stents versus bare-metal stents for percutaneous coronary intervention of the proximal left anterior descending artery: An analysis of the BASKET-PROVE I and II trials.
- Source :
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2018 Apr 01; Vol. 91 (5), pp. 867-873. Date of Electronic Publication: 2017 Jul 19. - Publication Year :
- 2018
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Abstract
- Objectives: To compare mid-term outcomes between patients undergoing proximal left anterior descending artery (LAD) percutaneous coronary intervention (PCI) with second generation drug-eluting stent (DES) or bare-metal stent (BMS).<br />Background: PCI with BMS and first-generation DES have shown to be safe options for the treatment of proximal LAD stenosis, however associated with considerable reintervention rates. Overall, second-generation DES has proven to be superior to BMS and first-generation DES, nevertheless, its effect for proximal LAD PCI has not previously been reported.<br />Methods: We analyzed 2-year outcomes of 1,100 patients from the BASKET-PROVE I and II trials, referred for proximal LAD PCI with second generation DES (n = 680) or BMS (n = 420).<br />Results: The cumulative 2-year incidence of major adverse cardiac events (MACE, composite of cardiac death, myocardial infarction (MI) and target vessel revascularization (TVR)) was lower in second generation DES than in BMS treated patients (7.3% vs. 12.3%; HR 0.57, 95% CI 0.39/0.85), mainly driven by a reduced rate of TVR (3.7% vs. 10.0%; HR 0.35, CI 0.21/0.58). No difference was found in cardiac death (1.9% vs. 1.9%; HR 1.01, CI 0.42/2.44) and MI (4.4% vs. 4.7%; HR 0.93, CI 0.53/1.64). The benefit of DES use seemed to be more prominent in female patients with a reduction in MACE (P for interaction = 0.025).<br />Conclusions: In patients with proximal LAD stenosis, treatment with second-generation DES was associated with reduced 2-year rates of adverse cardiac events and TVR compared to BMS, with reintervention rates similar to those earlier reported from bypass surgery.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease mortality
Coronary Stenosis diagnostic imaging
Coronary Stenosis mortality
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Myocardial Infarction etiology
Percutaneous Coronary Intervention adverse effects
Percutaneous Coronary Intervention mortality
Platelet Aggregation Inhibitors therapeutic use
Prosthesis Design
Randomized Controlled Trials as Topic
Risk Factors
Time Factors
Treatment Outcome
Coronary Artery Disease surgery
Coronary Stenosis surgery
Drug-Eluting Stents
Metals
Percutaneous Coronary Intervention instrumentation
Stents
Subjects
Details
- Language :
- English
- ISSN :
- 1522-726X
- Volume :
- 91
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
- Publication Type :
- Academic Journal
- Accession number :
- 28722266
- Full Text :
- https://doi.org/10.1002/ccd.27200