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Reproducibility for histologic parameters in peritoneal mesothelioma.
- Source :
-
Human pathology [Hum Pathol] 2017 Sep; Vol. 67, pp. 54-59. Date of Electronic Publication: 2017 Jul 13. - Publication Year :
- 2017
-
Abstract
- Histologic subtype is recognized as a prognostic factor in malignant pleural mesothelioma. Specifically, epithelial morphology is associated with a better prognosis than other subtypes, and the same association is observed in peritoneal malignant mesothelioma. Recently, prognostic differences based on morphologic subtypes of epithelial peritoneal malignant mesothelioma were reported. Herein, we report the interobserver variability across four pathologists at three institutions. The authors independently reviewed 67 cases of malignant peritoneal epithelioid mesotheliomas and subclassified them according to their epithelial subtype: papillary, tubulopapillary, trabecular, micropapillary, solid and/or pleomorphic. The cases were also evaluated by each author for several other histopathologic parameters including depth of invasion, nuclear grade, lymphocytic host response, mitotic count/index, presence of lymphovascular invasion, and stromal desmoplasia. The interobserver agreement for histopathologic parameters was highest for mitotic rate (κ=0.36) and primary epithelial subtype (κ=0.32). The interobserver variability for solid subtype pattern was moderate (κ=0.49). We found that the interobserver variability for most histopathologic parameters is poor.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor analysis
Biopsy
Epithelial Cells chemistry
Epithelioid Cells chemistry
Female
Humans
Immunohistochemistry
Male
Mesothelioma chemistry
Mesothelioma classification
Middle Aged
Mitotic Index
Neoplasm Grading
Neoplasm Invasiveness
Observer Variation
Peritoneal Neoplasms chemistry
Peritoneal Neoplasms classification
Predictive Value of Tests
Reproducibility of Results
United States
Young Adult
Epithelial Cells pathology
Epithelioid Cells pathology
Mesothelioma pathology
Peritoneal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 67
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 28712777
- Full Text :
- https://doi.org/10.1016/j.humpath.2017.07.005