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Hepatic steatosis in participants in a program of low-dose CT screening for lung cancer.
- Source :
-
European journal of radiology [Eur J Radiol] 2017 Sep; Vol. 94, pp. 174-179. Date of Electronic Publication: 2017 Jun 27. - Publication Year :
- 2017
-
Abstract
- Objective: Determine the frequency of moderate-to-severe hepatic steatosis (HS) in asymptomatic participants in a low-dose CT (LDCT) screening program for lung cancer, to identify risk factors, and develop recommendations.<br />Methods: Baseline LDCT scans of the chest of 170 participants in an IRB-approved study between August 2011 and April 2016 were reviewed. Demographic variables, comorbidities, and liver function tests were documented. Hepatic and splenic attenuation values hounsfield unit (HU) were measured. Regression analyses were performed.<br />Results: Average liver attenuation was 57.6HU (standard deviation (SD) 9.3) and average liver/spleen (L/S) ratio was 1.3 (SD 0.3). Liver attenuation was <40HU for 9 (5.3%), liver/spleen (L/S) ratio <0.8 for 6 (3.5%), and either <40HU or L/S ratio <0.8 for 9 (5.3%). Male sex (p=0.004), diabetes (p=0.0005), emphysema (p=0.03), and high BMI (p=0.0006) were significant predictors of HS. Aspartate aminotransferase (p=0.0018) and alanine aminotransferase (p=0.012) were negatively correlated with liver attenuation. Reduced serum levels of alpha-1-antitrypsin may be a common factor of emphysema and HS.<br />Conclusion: LDCT can detect HS in asymptomatic participants with frequencies similar to previous reports. If liver attenuation is below 40HU and/or L/S ratio below 0.8, further evaluation of HS to the primary care physician or liver specialist is recommended.<br /> (Copyright © 2017. Published by Elsevier B.V.)
- Subjects :
- Alanine Transaminase blood
Aspartate Aminotransferases blood
Female
Humans
Liver Function Tests
Lung Neoplasms blood
Male
Middle Aged
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Risk Factors
Sensitivity and Specificity
Fatty Liver diagnostic imaging
Lung Neoplasms diagnostic imaging
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 28712697
- Full Text :
- https://doi.org/10.1016/j.ejrad.2017.06.024