Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells.

Authors :: Samadi M
Nury T
Khalafi-Nezhad A
Lizard G
Source :: Steroids [Steroids] 2017 Sep; Vol. 125, pp. 124-130. Date of Electronic Publication: 2017 Jul 13.
Publication Year :: 2017
Abstract: We report the first Barton radical decarboxylation of unprotected bile acids via in situ irradiation of their thiohydroxamic esters in the presence of citraconic anhydride and citracoimide, leading to the synthesis a series of steroidal maleic anhydrides and maleimides as novel hybrid bile acids. The cytotoxic activities were evaluated on C6 rat glioma cells.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Chemistry Techniques, Synthetic
Decarboxylation
Drug Screening Assays, Antitumor
Free Radicals chemistry
Maleic Anhydrides chemistry
Maleimides chemistry
Rats
Bile Acids and Salts chemistry
Glioma pathology
Maleic Anhydrides chemical synthesis
Maleic Anhydrides pharmacology
Maleimides chemical synthesis
Maleimides pharmacology

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