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Dynamics of Torque Teno virus plasma DNAemia in allogeneic stem cell transplant recipients.
- Source :
-
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2017 Sep; Vol. 94, pp. 22-28. Date of Electronic Publication: 2017 Jul 08. - Publication Year :
- 2017
-
Abstract
- Background: Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT).<br />Objectives: We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT.<br />Study Design: Retrospective single-center observational study including 72 allo-HSCT patients. Plasma TTV DNA loads were quantified before initiating the conditioning regimen and at different time-points after transplant by real-time PCR. White blood cells (WBC) and absolute lymphocyte counts (ALC) were measured by flow cytometry.<br />Results: A dramatic drop in plasma TTV DNA load was observed shortly after conditioning. The TTV DNA load increased steadily after engraftment reaching its peak at day +90 after transplant. The increase in TTV DNA load paralleled that of ALC, and was of greater magnitude in patients who developed severe (grades II-IV) acute graft vs. host disease.<br />Conclusion: Repopulation of lymphocytes early after allo-HSCT correlates with an increase of plasma TTV DNA load. Prospective studies are nevertheless needed to determine whether the kinetics of TTV DNAemia may allow inference of the degree of overall immunocompetence in these patients.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
DNA Virus Infections blood
DNA Virus Infections immunology
Female
Humans
Immunocompromised Host
Leukocyte Count
Male
Middle Aged
Retrospective Studies
Transplantation, Homologous
Viral Load
Viremia virology
Young Adult
DNA Virus Infections virology
DNA, Viral blood
Hematopoietic Stem Cell Transplantation
Torque teno virus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5967
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Publication Type :
- Academic Journal
- Accession number :
- 28710997
- Full Text :
- https://doi.org/10.1016/j.jcv.2017.07.001