Back to Search
Start Over
The Cellular and Molecular Mechanism of Radiation-Induced Lung Injury.
- Source :
-
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2017 Jul 15; Vol. 23, pp. 3446-3450. Date of Electronic Publication: 2017 Jul 15. - Publication Year :
- 2017
-
Abstract
- The lung is one of several moderately radiosensitive organs. Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced pulmonary fibrosis, occurs most often in radiotherapy of lung cancer, esophageal cancer, and other thoracic cancers. Clinical symptoms of RILI include dry cough, shortness of breath, chest pain, fever, and even severe respiratory failure and death. The occurrence of RILI is a complex process that includes a variety of cellular and molecular interactions which ultimately leads to large fibroblast accumulation, proliferation, and differentiation, resulting in excessive extracellular matrix deposits, causing pulmonary fibrosis. The progress that has been made in recent years in the understanding of cellular and molecular mechanisms of RILI is summarized in this review.
- Subjects :
- Abnormalities, Radiation-Induced metabolism
Alveolar Epithelial Cells radiation effects
Cytokines radiation effects
Endothelial Cells radiation effects
Fibroblasts radiation effects
Humans
Lung metabolism
Lung physiology
Lung Injury metabolism
Lung Neoplasms complications
Macrophages radiation effects
Pulmonary Fibrosis etiology
Lung radiation effects
Radiation Injuries drug therapy
Radiation Pneumonitis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1643-3750
- Volume :
- 23
- Database :
- MEDLINE
- Journal :
- Medical science monitor : international medical journal of experimental and clinical research
- Publication Type :
- Academic Journal
- Accession number :
- 28710886
- Full Text :
- https://doi.org/10.12659/msm.902353