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What Happens to Blood Glucose Concentrations After Oral Treatment for Neonatal Hypoglycemia?

Authors :
Harris DL
Gamble GD
Weston PJ
Harding JE
Source :
The Journal of pediatrics [J Pediatr] 2017 Nov; Vol. 190, pp. 136-141. Date of Electronic Publication: 2017 Jul 11.
Publication Year :
2017

Abstract

Objective: To determine the change in blood glucose concentration after oral treatment of infants with hypoglycemia in the first 48 hours after birth.<br />Study Design: We analyzed data from 227 infants with hypoglycemia (blood glucose <46.8 mg/dL, 2.6 mmol/L) born at a tertiary hospital who experienced 295 episodes of hypoglycemia. Blood glucose concentrations were measured (glucose oxidase) within 90 minutes after randomization to dextrose or placebo gel plus feeding with formula, expressed breast milk, or breast feeding.<br />Results: The overall mean increase in blood glucose concentration was 11.7 mg/dL (95% CI 10.4-12.8). The increase was greater after buccal dextrose gel than after placebo gel (+3.0 mg/dL; 95% CI 0.7-5.3; P = .01) and greater after infant formula than after other feedings (+3.8 mg/dL; 95% CI 0.8-6.7; P = .01). The increase in blood glucose concentration was not affected by breast feeding (+2.0 mg/dL; 95% CI -0.3 to 44.2; P = .09) or expressed breast milk (-1.4 mg/dL; 95% CI -3.7 to 0.9; P = .25). However, breast feeding was associated with reduced requirement for repeat gel treatment (OR = 0.52; 95% CI 0.28-0.94; P = .03).<br />Conclusions: Treatment of infants with hypoglycemia with dextrose gel or formula is associated with increased blood glucose concentration and breast feeding with reduced need for further treatment. Dextrose gel and breast feeding should be considered for first-line oral treatment of infants with hypoglycemia.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1097-6833
Volume :
190
Database :
MEDLINE
Journal :
The Journal of pediatrics
Publication Type :
Academic Journal
Accession number :
28709629
Full Text :
https://doi.org/10.1016/j.jpeds.2017.06.034