In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses.

Authors :: Oktaria S
Lerch MLF
Rosenfeld AB
Tehei M
Corde S
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2017 Oct; Vol. 128, pp. 114-119. Date of Electronic Publication: 2017 Jul 06.
Publication Year :: 2017
Abstract: Radiation therapy is rapidly evolving toward the delivery of higher dose rates to improve cancer treatment. In vitro experiments were performed to investigate the response of 9L and MCF-7 cancer cell lines, exposed to 10MV X-ray radiations. Up to 8Gy was delivered at a dose-rate of 50cGy/min compared to 5Gy/min. The data obtained emphasizes the importance of taking into account not only the physical, but also the radiobiological parameters, when planning a particular cancer treatment.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Subjects :: Cell Survival radiation effects
Dose-Response Relationship, Drug
Humans
In Vitro Techniques
MCF-7 Cells
Neoplasms radiotherapy
Radiotherapy, Intensity-Modulated
Radiotherapy Dosage
Relative Biological Effectiveness

Language :: English
ISSN :: 1872-9800
Volume :: 128
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 28709028
Full Text :: https://doi.org/10.1016/j.apradiso.2017.07.008

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