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Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers.
- Source :
-
Pharmaceutical research [Pharm Res] 2017 Oct; Vol. 34 (10), pp. 2000-2011. Date of Electronic Publication: 2017 Jul 13. - Publication Year :
- 2017
-
Abstract
- The subcutaneous route offers myriad benefits for the administration of biotherapeutics in both acute and chronic diseases, including convenience, cost effectiveness and the potential for automation through closed-loop systems. Recent advances in parenteral administration devices and the use of additives which enhance drug dispersion have generated substantial additional interest in IV to SQ switching studies. Designing pre-clinical and clinical studies using SQ mediated delivery however requires deep understanding of complex inter-related physiologies and transport pathways governing the interstitial matrix, vascular system and lymphatic channels. This expert review will highlight key structural features which contribute to transport and biodistribution in the subcutaneous space and also assess the impact of drug formulations. Based on the rapidly growing interest in the SQ delivery route, a number of potential areas for future development are highlighted, which are likely to allow continued evolution and innovation in this important area.
- Subjects :
- Animals
Antibodies, Monoclonal metabolism
Antibodies, Monoclonal pharmacology
Biological Availability
Chemistry, Pharmaceutical
Drug Delivery Systems mortality
Drug Liberation
Humans
Permeability drug effects
Tissue Distribution drug effects
Antibodies, Monoclonal administration & dosage
Antibodies, Monoclonal chemistry
Infusions, Subcutaneous methods
Injections, Subcutaneous methods
Subjects
Details
- Language :
- English
- ISSN :
- 1573-904X
- Volume :
- 34
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pharmaceutical research
- Publication Type :
- Academic Journal
- Accession number :
- 28707164
- Full Text :
- https://doi.org/10.1007/s11095-017-2229-9