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Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation.
- Source :
-
Physiological reports [Physiol Rep] 2017 Jul; Vol. 5 (13). Date of Electronic Publication: 2017 Jul 11. - Publication Year :
- 2017
-
Abstract
- Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered following high-intensity interval training (HIIT) in a group of 13 lifelong sedentary (SED; 64 [6] years) and 11 lifelong exercising (LEX; 62 [6] years) older males. SED follistatin was moderately greater than LEX pre-HIIT (Cohen's d  = 0.66), and was largely greater post-HIIT (Cohen's d  = 1.22). The HIIT-induced increase in follistatin was large in SED (Cohen's d  = 0.82) and absent in LEX (Cohen's d  = 0.03). GDF11 was higher in LEX pre-HIIT (Cohen's d  = 0.49) and post-HIIT (Cohen's d  = 0.63) compared to SED HIIT resulted in no change to GDF11 in LEX or SED (Cohen's d  = 0.00-0.03). Peak power output and GDF11 were correlated ( r  = 0.603), independent of grouping. Differences in GDF11 with lifelong exercise training, paired with the correlation between GDF11 and peak power output, suggested that GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans, and strategies to maintain this need to be further explored.<br /> (© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
Details
- Language :
- English
- ISSN :
- 2051-817X
- Volume :
- 5
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Physiological reports
- Publication Type :
- Academic Journal
- Accession number :
- 28701523
- Full Text :
- https://doi.org/10.14814/phy2.13343