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Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2018 Apr; Vol. 1417 (1), pp. 35-56. Date of Electronic Publication: 2017 Jul 12. - Publication Year :
- 2018
-
Abstract
- Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Although considerable effort has been devoted to understanding the biological function of MSCs, additional resources are required to clarify the mechanisms of their induction of immune tolerance, which will undoubtedly lead to improved clinical outcomes for MSC-based therapies.<br /> (© 2017 New York Academy of Sciences.)
- Subjects :
- Animals
B-Lymphocytes immunology
Cell- and Tissue-Based Therapy
Clinical Trials as Topic
Dendritic Cells immunology
Humans
Immune Tolerance
Macrophages immunology
Mesenchymal Stem Cell Transplantation
Models, Immunological
Monocytes immunology
T-Lymphocytes immunology
Mesenchymal Stem Cells immunology
Transplantation Tolerance immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1417
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28700815
- Full Text :
- https://doi.org/10.1111/nyas.13364