Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients.

Authors :: Lisboa Neto G
Malta FM
Gomes-Gouvêa MS
Noble CF
Romano CM
Rebello Pinho JR
Silva MH
Leite AGB
Piccoli LZ
Carrilho FJ
Mendes-Correa MC
Source :: Journal of medical virology [J Med Virol] 2017 Dec; Vol. 89 (12), pp. 2249-2254. Date of Electronic Publication: 2017 Aug 11.
Publication Year :: 2017
Abstract: Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6-2.4%), V55A (7-2.8%), and Q80R (2-0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs. Advanced liver fibrosis and HIV co-infection were not related to NS3/NS4A amino acid substitutions.<br /> (© 2017 Wiley Periodicals, Inc.)

Full Text Access

Tools