Back to Search
Start Over
Safety of available and emerging drug therapies for hyperhidrosis.
- Source :
-
Expert opinion on drug safety [Expert Opin Drug Saf] 2017 Sep; Vol. 16 (9), pp. 1039-1049. Date of Electronic Publication: 2017 Jul 16. - Publication Year :
- 2017
-
Abstract
- Introduction: Hyperhidrosis affects 4.8% of the U.S. population and has been underestimated by physicians for long time despite considerable interference with quality of life. Many patients suffer from primary (idiopathic) hyperhidrosis which results from over-activity of sympathetic nerves and is restricted to specific body areas, mostly the axillae, palms, soles, or head. Secondary hyperhidrosis is caused by an underlying disease or the intake of medications and often involves large parts of the body. Numerous effective therapies with topical or systemic drugs and surgical options are available. Areas covered: Efficacy and safety data on aluminum salts, anticholinergic drugs for topical or systemic application, and on intradermal botulinum toxin injections used to treat hyperhidrosis are critically evaluated, including data from clinical trials with focus on possible side effects and long-term complications in dispute. Expert opinion: Hyperhidrosis often responds well to available therapies. Depending on the type of hyperhidrosis treatment should be topical/local or systemic. Most of the side effects are mild, transient and easily manageable. In case of systemic treatment with anticholinergics low dosing and up-titration of medication is necessary to avoid severe adverse effects. Concerns about the promotion of breast cancer and Alzheimer disease by topical aluminum salts are unsolved.
- Subjects :
- Administration, Topical
Aluminum Compounds administration & dosage
Aluminum Compounds adverse effects
Animals
Botulinum Toxins administration & dosage
Botulinum Toxins adverse effects
Cholinergic Antagonists administration & dosage
Cholinergic Antagonists adverse effects
Humans
Hyperhidrosis physiopathology
Hyperhidrosis drug therapy
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1744-764X
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 28699790
- Full Text :
- https://doi.org/10.1080/14740338.2017.1354983