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Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.

Authors :
Mire CE
Geisbert TW
Source :
Trends in molecular medicine [Trends Mol Med] 2017 Aug; Vol. 23 (8), pp. 669-671. Date of Electronic Publication: 2017 Jul 08.
Publication Year :
2017

Abstract

The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to establish infection of a cell and therefore, represents an important target of both vaccines and antivirals. The latest reports on pan-ebolavirus monoclonal antibodies in small animal models may offer promising outcomes and insight into how best to target the GP in vaccine and antiviral discovery.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Subjects

Subjects :
Animals
Ebola Vaccines immunology
Ebola Vaccines therapeutic use
Hemorrhagic Fever, Ebola immunology
Hemorrhagic Fever, Ebola pathology
Humans
Viral Fusion Proteins immunology
Antibodies, Monoclonal immunology
Antibodies, Monoclonal therapeutic use
Antibodies, Neutralizing immunology
Antibodies, Neutralizing therapeutic use
Antibodies, Viral immunology
Antibodies, Viral therapeutic use
Ebolavirus immunology
Hemorrhagic Fever, Ebola prevention & control

Details

Language :
English
ISSN :
1471-499X
Volume :
23
Issue :
8
Database :
MEDLINE
Journal :
Trends in molecular medicine
Publication Type :
Academic Journal
Accession number :
28697885
Full Text :
https://doi.org/10.1016/j.molmed.2017.06.008
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