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[ 18 F]FDOPA positron emission tomography in manganese-exposed workers.
- Source :
-
Neurotoxicology [Neurotoxicology] 2018 Jan; Vol. 64, pp. 43-49. Date of Electronic Publication: 2017 Jul 08. - Publication Year :
- 2018
-
Abstract
- Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neuronal function. 6-[ <superscript>18</superscript> F]fluoro-L-DOPA (FDOPA) PET reflects in-vivo nigrostriatal function, but results in Mn exposure are conflicting. The objective of this study was to investigate the association between Mn exposure secondary to occupational welding, FDOPA striatal uptake, and clinical parkinsonism as measured by Unified Parkinson Disease Rating Scale motor subscore 3 (UPDRS3) scores. FDOPA PET scans were acquired on 72 subjects (27 Mn-exposed welders, 14 other Mn-exposed workers, and 31 non-exposed subjects). We estimated cumulative welding exposure from detailed work histories, and a movement disorders specialist examined all subjects. Striatal volumes of interest were identified on aligned magnetic resonance imaging (MRI) for each subject. Specific striatal FDOPA uptake was calculated with a graphical analysis method. We used linear regression while adjusting for age to assess the association between welding exposure and FDOPA uptake in the caudate, anterior putamen, and posterior putamen. Compared to the non-exposed subjects, mean caudate FDOPA uptake was 0.0014min <superscript>-1</superscript> (95% confidence interval [CI] 0.0008, 0.0020) lower in Mn-exposed welders and 0.0012min <superscript>-1</superscript> (95% CI 0.0005, 0.0019) lower in other Mn-exposed workers (both p≤0.001). There was no clear dose-response association between caudate FDOPA uptake and Mn exposure or UPDRS3 scores. Mn-exposed welders and workers demonstrated lower caudate FDOPA uptake, indicating pre-synaptic dopaminergic dysfunction in Mn-exposed subjects that was not associated with clinical parkinsonism.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Corpus Striatum diagnostic imaging
Cross-Sectional Studies
Dihydroxyphenylalanine analogs & derivatives
Female
Humans
Magnetic Resonance Imaging
Male
Manganese Poisoning diagnostic imaging
Middle Aged
Occupational Diseases chemically induced
Occupational Diseases diagnostic imaging
Parkinsonian Disorders diagnostic imaging
Parkinsonian Disorders metabolism
Positron-Emission Tomography
Welding
Corpus Striatum metabolism
Manganese Poisoning metabolism
Occupational Diseases metabolism
Occupational Exposure
Parkinsonian Disorders chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9711
- Volume :
- 64
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 28694016
- Full Text :
- https://doi.org/10.1016/j.neuro.2017.07.004